Common Runtime Tools in 2025

ToolBest ForRuns onSupports Quantized?InterfaceNotes
OllamaPlug-and-play local LLMsCPU/GPU (cross-platform)✅ Yes (.gguf)CLI, REST APISimplest tool. Great user experience. Limited customization.
llama.cppFast, portable inferenceCPU/GPU (CUDA, Metal, ROCm)✅ Yes (.gguf)CLI, APISuper efficient, no Python needed, often used as backend.
text-generation-webuiMaximum flexibility & featuresGPU (CUDA), CPU✅ Yes (.gguf, .pth)Web UI, APIHugely popular. Supports multiple models, LoRA, streaming, plugins.
vLLMHigh-throughput, OpenAI-style inferenceGPU❌ (full precision only)API (OpenAI-style)Blazing fast for multi-user apps. Not for quantized models.
TGI (Text Gen Inference)Production-grade model hostingGPU❌ (full models only)APIFrom Hugging Face. For scalable, fast deployment.
LM StudioGUI-based local model runnerGPU/CPU (Windows/macOS)✅ Yes (.gguf)Desktop GUIGreat for beginners. Drag-and-drop style model loading.
llamafileSelf-contained binaries (model + runtime)CPU/GPU✅ Yes (.gguf)CLI, APILike a portable .exe for models. No install needed.
AutoGPTQQuantized model inference (GPTQ format)GPU✅ GPTQ onlyPython scriptsFor developers using GPTQ quantization.

Comparison Summary

FeatureOllamallama.cpptext-gen-webuivLLMLM Studio
Ease of Use⭐⭐⭐⭐⭐⭐⭐⭐⭐⭐⭐⭐⭐⭐⭐⭐⭐⭐
Quantization Support
GPU Acceleration
LoRA / Fine-tune Plugins⚠️ (partial)
Multi-Model Switching⚠️ (manual)⚠️ (restarts needed)⚠️ (manual)
API Exposure
Local-Only Privacy

File Formats by Runtime

FormatUsed ByDescription
.ggufllama.cpp, Ollama, LM StudioQuantized models (efficient for CPU/GPU)
.safetensorsHugging Face, text-gen-webuiFull-precision PyTorch weights
.binLegacy modelsOlder format, being phased out
.ggmlllama.cpp (older)Predecessor to .gguf, still seen in some models
.pt/.pthPyTorchFull-precision, often used before quantization
.ggqtAutoGPTQSpecialized GPTQ quantized weights

When to Use What

Use CaseRecommended Tool
Just want to run a model quicklyOllama or LM Studio
Want web UI + LoRA supporttext-generation-webui
Maximum performance, CLI usellama.cpp
High-performance web app backendvLLM
Self-contained model (portable .exe)llamafile